Male Factor Infertility


In nearly half of infertility cases, the reason for not getting pregnant is due to a sperm factor. This can be identified by careful interpretation of a standard semen analysis. Additionally, the Y-chromosome microdeletion test is an important genetic test to consider during the male factor evaluation. Dr. Sills often works collaboratively with reproductive urologists to help identify potential causes for abnormal sperm findings.

A more recent diagnostic test that can be useful in selected cases, where a male factor diagnosis is suspected, is known as the sperm chromatin structure assay (SCSA). This test measures the integrity of DNA located within the sperm nucleus, a parameter that will not be measured in a standard semen analysis. Although still regarded by some as an investigational test, SCSA can provide valuable information to assist in planning fertility treatments.

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E. Scott Sills, MD PhD and the Center for Advanced Genetics (CAG) is a reproductive medicine clinic located in Carlsbad, California USA, in North San Diego County, and serves the cities of Carlsbad, Oceanside, Vista, San Marcos, Encinitas, Escondido, Fallbrook, Bonsall, and Camp Pendleton. The fertility clinic specializes in in-vitro fertilization (IVF), frozen embryo transfer (FET), blastocyst transfer, pre-implantation genetic diagnosis/screening/testing of embryos (PGD, PGS) for possible genetic abnormalities and gender selection, Next Generation Sequencing (NGS), intra-uterine insemination (IUI), surrogacy, donor cycles, male-factor infertility, Essure® removal, treatment for recurrent pregnancy loss, and fertility preservation (egg freezing, sperm banking). Dr. Sills is published over 100 times in peer-reviewed publications and just published his book “Fighting at the Fertility Front,” a book that covers infertility, treatments, and issues that are unique to military personnel. CAG is committed to building families, including assisting those of the LGBT community. We offer low-interest fertility treatment financing to make having a baby a reality for virtually everyone.
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